Background: Post-operative nausea and vomiting (PONV) is a common and distressing complication after anaesthesia and surgery. The present study was conducted to determine the effect of dextrose in LC patients in preventing PONV. Materials & Methods: The present study was conducted on 200 patients of both genders. All were selected for LC under general anesthesia. They were divided into 2 groups. Group I patients received an infusion of 500 cc lactated Ringer’s solution and group II received 5% dextrose in lactated Ringer’s solution over a period of 30 min. All patients rated their nausea and vomiting intensity using the verbal rating scale immediately at post‑anaesthesia care unit arrival; 60 and 120 min after arriving at the PACU and 12 and 24 h after surgery. Results: Nausea score at 60 minutes (N1) was 1 in group II and 5.2 in group I, N2 was 0.86 in group II and 4.2 in group I, N3 was 1.24 in group II and 2.84 in group I and N4 was 0.2 in group II and 0.1 in group I. The difference was significant (P< 0.05). Vomiting score T1 was 5.26 in group I and 1 in group II, T2 was 1.32 in group I and 0.63 in group II, T3 was 2.48 in group I and 1.24 in group II and T4 was 1.42 in group I and 0.82 in group II. The difference was statistically significant (P< 0.05). Conclusion: Author found that administration of IV dextrose before anaesthesia induction may be recommended as an effective and safe method for the prophylaxis of PONV after LC. Key words: Dextrose, Nausea, Vomiting